The pair were rested for the Champions League clash against Olympiakos on Wednesday, though City faired okay without them, winning 1-0 away from home thanks to a solitary goal from Phil Foden.
Foden will be hoping his match winning performance in Europe will be enough to earn him a start in the Premier League versus the Clarets.
Guardiola is close to having a full squad at his disposal after Benjamin Mendy and Fernandinho made their returns during the week.
Nathan Ake is the only doubt as he is yet to fully recover from injury, but has returned to training.
The return of Walker will likely mean a rest for Joao Cancelo who has played across various positions recently, while Aymeric Laporte will come into the centre of defence after John Stones was given a rare start against Olymiakos.
With City likely to see plenty of the ball against Burnley, Guardiola may opt to play De Bruyne in a deeper role and encouraged to move forward rather than play to sitting midfielders.
Raheem Sterling and Ferran Torres should start in the three behind the striker alongside Foden.
Up top, Sergio Aguero is ready to make the starting line-up.