Dortmund are carrying a 3-2 away win into the second leg, with the tie remaining in the balance despite their away goals advantage.
Marcel Schmelzer and Manuel Akanji are ruled out in defence while Raphael Guerreiro also has an injury cloud hovering above his head.
Marwin Hitz should continue in goal having taken the No.1 spot from Roman Burki in January, playing every game since.
Akanji’s absence is likely to force Emre Can back into the centre of defence alongside Mats Hummels with Meunier on the right and Guerreiro to the left as he is set to be given every opportunity to prove his fitness.
Mahmoud Dahoud scored a beauty in the first leg and should continue in midfield, with Thomas Delaney likely to be paired alongside him.
Giovanni Reyna is also unlikely to feature, leaving the attacking midfield stocks looking rather bare heading into the match.
The Norwegian star had a hand in all three goals in the first leg with a brace and an assist, and currently leads the Champions League golden boot race with eight goals in the competition.
He will remain fixed in place up front and will eye a similarly early impact as the one against Bayern as Dortmund look to make good on their away goal advantage as quickly as possible.