Last week, they comfortably defeated Ludogorets in London with a 4-0 home victory, with two goals from Carlos Vinicius and strikes from Harry Winks and Lucas Moura claiming all three points in Group J.
Vinicius and Moura expected to start this one again, with Gareth Bale and Dele Alli also coming in to make up the same front four that started against LASK.
Dele has been left out of squads altogether by Mourinho this season, with speculation mounting that he could leave Spurs in January. However, against LASK last week he enjoyed one of his more positive performances of the season, earning a 7.8 FC Rating.
Giovani Lo Celso is pushing for a start, and could come in for a deeper role in midfield alongside Winks, who scored a spectacular long range goal from the left wing a week ago.
Ben Davies will come in at left-back, with Davinson Sanchez and Japhet Tanganga starting in the centre of the defence.
Matt Doherty will replace Serge Aurier at right-back, with Joe Hart starting in goal.
Toby Alderweireld misses out after a confirmed groin injury.