As things stand in Group J, Spurs are second with 10 points taken from their opening five matches, while the Belgian side are two points ahead on 12.
Antwerp just need a point to top the group, while Spurs need to win if they want to emerge as group winners and earn a favourable draw for the knockout stage.
Spurs' only defeat of the group stage came at the hands of Antwerp, who won 1-0 in Belgium thanks to a solitary goal from Lior Refaelov.
Mourinho usually heavily rotates his starting XI from the Premier League to the Europa League, and will likely name a front four which has become a staple of their campaign in the group stage.
Bale, Dele, Lucas Moura, and Carlos Vinicius will all likely start this one.
Harry Winks will come in to the centre of midfield, probably partnered by Moussa Sissoko instead of Giovani Lo Celso.
In a fully changed back four, Japhet Tanganga, Matt Doherty, Davinson Sanchez, and Ben Davies will probably be recalled.
In goal is a tough choice for Mourinho as Joe Hart did not cover himself in glory in the previous game against LASK which ended 3-3.
The Portuguese boss could ask Hugo Lloris to step in, but it is likely he'll keep faith with Hart for now.