Leonardo Bonucci will be given a late fitness test to see if he can feature in Juventus' match against Benevento in Serie A.
However, at this point it seems unlikely that the Italy international will recover in time, or be risked, by Andrea Pirlo.
That means that Pirlo will have to utilise a back four, probably the same back four that featured against Ferencvaros in the Europa League.
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The foursome of Juan Cuadrado, Matthijs de Ligt, Danilo, and the returning Alex Sandro didn't look too comfortable against the Hungarian side.
But, with Bonucci, Giorgio Chiellini, and Merih Demiral all out or doubtful at the moment, the Juve boss' hands are somewhat tied.
Against Ferencvaros, Weston McKennie starting to the right of the four-man midfield but was eventually subbed after an ineffectual outing, which could mean a return to the starting XI for Dejan Kulusevski.
On the other wing, Federico Chiesa could replace Federico Bernardeschi.
Paulo Dybala was handed a rare start by Pirlo up front against Ferencvaros alongside Cristiano Ronaldo.
But, Alvaro Morata will likely be recalled for this one at the Argentine's expense, especially since he scored the late winner in the Champions League midweek.
Juventus: Squad, FC Ratings, Matches, Formations
Juventus starting XI versus Benevento
Cristiano Ronaldo 
Álvaro Morata 
Paulo Dybala 
Juventus 
Benevento