Arsenal made hard work of Greek side Olympiakos, eventually winning 3-1 away from home. Spurs, meanwhile, won 2-0 in what was a comfortable game against Dinamo Zagreb at home.
Both Mikel Arteta and Jose Mourinho are expected to ring the changes for the derby, with both having rotated for the Europa League.
For the home side, Arteta has no injury concerns. Pablo Mari is expected to return at the heart of the defence for the Gunners, having missed the game against Olympiakos.
Mari will likely replace Gabriel to play alongside David Luiz. Hector Bellerin and Kieran Tierney will occupy both flanks.
In midfield, Arteta is likely to retain the same midfield as he did in midweek. Martin Odegaard scored his first goal for Arsenal against Olympiakos, and he's likely to maintain his place behind the forwards.
Granit Xhaka, Thomas Partey and Bukayo Saka are also expected to play from the off against Spurs.
In attack, Nicolas Pepe will keep his place alongside Pierre-Emerick Aubameyang.
Tottenham, meanwhile, are expected to also ring the changes.
Mourinho heavily rotated his backline for the win against the Croatian side in midweek, so expected Eric Dier, Ben Davies and Serge Aurier all to make way for the returning Toby Alderweireld, Sergio Reguilon and Matt Doherty.
In midfield, Pierre-Emile Hojbjerg was rested, and therefore is expected to start on Sunday alongside Tanguy Ndombele. Moussa Sissoko is expected to drop to the bench.
In the attacking three places, Gareth Bale is thought to be due to start after being rested against Zagreb. Lucas Moura and Heung-min Son are also believed to be in line to start.
Harry Kane picked up a small injury against Zagreb but is expected to recover and lead the line for Mourinho's men.