Sergio Ramos made a triumphant return from injury in the weekend Clasico against Barcelona and Zinedine Zidane needs another big performance from his captain against Borussia Monchengladbach.
Ramos shrugged off a knee problem to slot home a crucial penalty in the clash and he will line up alongside and Raphael Varane here, with Ferland Mendy likely to play left-back.
Nacho became the third right-back to get injured alongside Alvaro Odriozola and Dani Carvajal in the Barca match, but Lucas Vazquez was superb after coming on and he could be utilised there in the next few matches.
Ahead of him Casemiro, Fede Valverde and Toni Kroos all had excellent matches in the Clasico but so did Luka Modric when he came on and with Valverde carrying a slight knock the Croatian is likely to start.
Ahead of him Karim Benzema will play after being rested last week against Shakhtar - that decision didn't work out - and Vinicius Jr will likely keep his place. On the right Marco Asensio worked hard in a thankless role and he might be rotated out for Rodrygo here.
Martin Odegaard is out until after the international break, as is Eden Hazard.