Under siege coach Andrea Pirlo needs a victory on the final day of the season to secure a top four finish for Juventus, and hope other results go in his favour.
Juventus were dethroned this season after their nine-year dominance of the Italian game was ended by Inter.
Their collapse has been so extraordinary that there's a real possibility that they might not qualify for Champions League football.
Juve won the Coppa Italia in midweek, beating Atalanta 2-1 in Reggio Emilia thanks to goals from Dejan Kulusevski and Federico Chiesa.
They currently sit fifth, and need Milan or Napoli to slip up in order to cement a top four finish.
Wojciech Szczesny is due to start in goal, and in front of him will be Matthijs de Ligt, Danilo, Giorgio Chiellini and Alex Sandro.
In midfield, Pirlo is again expected to go with a four-man midfield, comprising of Juan Cuadrado, Arthur, Chiesa and Adrien Rabiot.
Cristiano Ronaldo, who could be playing his final game for Juventus, will start alongside Paulo Dybala - who could also follow Ronaldo out the Turin exit door.
Kulusevski and Alvaro Morata will drop to the bench, but could come on should things prove to be a little tricky against Sinisa Mihajlovic's dogged Bologna side.
Gianluigi Buffon, who has already announced that he's leaving the club at the end of the season for the second time in his career, is unlikely to get any minutes on the final day, having started in the Coppa Italia final.