Barcelona will be without star winger Ansu Fati for Sunday's La Liga fixture against Alaves.
The young Spaniard has fought injury issues constantly in his short career and has suffered another setback as against Athletic Bilbao on Thursday he was forced to withdraw, eventually leaving the pitch in tears.
It is believed he could be missing for up to six weeks.
Samuel Umtiti recently signed a new contract with Barcelona but he is set to miss much of the remainder of the season due to injury.
Gavi will be missing for this one due to a suspension after being dismissed against Granada.
Like Fati, Pedri also had to come off injured in the Copa del Rey loss against Athletic Bilbao, but his problem is not believed to be serious so he should feature versus Alaves.
Memphis Depay remains a doubt, while Ousmane Dembele will likely not play for Barcelona again after being told to leave the club this month.
Marc-Andre ter Stegen will start in goal behind a back four of Dani Alves, Ronald Araujo, Gerard Pique and Jordi Alba.
With Gavi unavailable, Nico will come into the midfield three alongside Sergio Busquets and Frenkie de Jong.
Barca are desperately short of options in attack so Ferran Jutgla might start again, with Luuk de Jong recalled.
Ferran Torres will continue, too.