Atletico Madrid take on Barcelona at the Wanda Metropolitano on Saturday evening with both teams desperate to pick up points to keep up the pace with Real Madrid.
Los Colchoneros have won four out of their opening seven games in La Liga so far and last week suffered their first defeat of the campaign - a 1-0 loss against Alaves.
Barca, meanwhile, are unbeaten but have only won half of their six games, drawing the other three versus Athletic Bilbao, Granada and Cadiz.
The Blaugrana's season went from bad to worse during the week as they were defeated 3-0 in the Champions League by Benfica, whereas Atletico earned a positive 2-1 result away at Milan.
Diego Simeone has only one injury concern and that is Kieran Trippier as the England international was forced off before half-time in Milan.
Should he be unfit to play, then Marcos Llorente could be asked to play at right-back alongside Jose Gimenez, Stefan Savic and Renan Lodi.
Jan Oblak will start in goal.
If Simeone goes with a 4-4-2 again, Rodrigo De Paul could be asked to play on the right instead of Llorente, wth Koke and Geoffrey Kondogbia in the middle and Yannick Carrasco on the left.
Antoine Griezmann scored his first goal since returning to the club against Milan, so he might be selected to partner Luis Suarez instead of Angel Correa.
As for Barcelona, Ronald Koeman is now under major pressure to deliver results and any defeat here could spell the end for the Dutchman.
A back three was expiremented with against Benfica but we will likely see a 4-3-3 against Atletico, with Sergi Roberto at right-back, Gerard Pique and Ronald Araujo in the middle and Sergino Dest on the left.
Frenkie de Jong, Sergio Busquets and Pedri will likely start in the midfield three, with Philippe Coutinho and Memphis Depay supporting Luuk de Jong in attack.
Ansu Fati has returned from injury but the club are being careful with his recovery so we will probably only see him from the bench.
Ousmane Dembele, Sergio Aguero, Jordi Alba, Martin Braithwaite, and Alejandro Balde are injured.