Tottenham boss Jose Mourinho is likely to rotate his squad for the challenge of Crystal Palace.
The Portuguese boss started all four of Harry Kane, Gareth Bale, Son Heung-min and Dele Alli in the slender 1-0 win against Fulham in midweek.
However it seems unlikely that he will do it for a second consecutive game, with changes expected.
Alli looks likely to be the man to drop out of the starting XI in place of Lucas Moura, after the Brazilian impressed after coming on in the game against Fulham.
In defence, Mourinho is likely to start Serge Aurier and Sergio Reguilon in the full-back positions.
In central defence, Toby Alderweireld is expected to start alongside Davinson Sanchez.
Mourinho is expected to keep faith in the two-man partnership of Tanguy Ndombele and Pierre-Emile Hojbjerg, despite the pair looking fatigued against Fulham.
Moussa Sissoko and Harry Winks are expected to start in the Europa League Round of 16 game against Dinamo Zagreb next week, and so are unlikely to feature against Roy Hodgson's men.
Lucas Moura is expected to replace Dele Alli in one of the attacking positions, and the Brazilian will likely play alongside Bale and Son, with Harry Kane leading the line.
Carlos Vinicius and Erik Lamela may come off the bench, should they be needed.
Giovani Lo Celso is likely to remain unavailable but could return from a long-term hamstring injury on Thursday night.