Sevilla have closed the gap at the top of the table to five points after a narrow win over Getafe on Sunday afternoon.
Rafa Mir scored the only goal of the game on 22 minutes to narrow Real Madrid's lead, with Sevilla still having a game in hand.
Karim Benzema opened the scoring for the home side in the first half from the penalty spot before a double from Vini Jr pushed them well clear. Valencia got one back through Goncalo Guedes after his penalty was stopped, but Benzema capped a memorable evening upon which he scored his 300th goal for the club by netting two minutes from the end.
Sergio Canales put 10-men Betis ahead in first-half injury time but Ivan Balliu earned Rayo a point.
Luuk de Jong scored his second goal in as many matches for the club but Gavi was dismissed for two yellow cards and the home side found a late equaliser through Antonio Puertas.
In the other game pertinent to the European places on Saturday, Real Sociedad rediscovered some of their early season form to defeat Celta Vigo 1-0 thanks to a goal from Mikel Oyarzabal after 13 minutes. They were incredibly disciplined thereafter, not conceding a single shot on target over the course of the match.
Athletic Bilbao's own top four hopes decreased as they could only draw 0-0 at Alaves.
At the foot of the table, meanwhile, there was a first victory of the season for Levante, who defeated Mallorca 2-0. They remain rooted to the foot of the standings but this success has given them faint hope of survival.
Nineteenth-placed Cadiz lost 2-0 at Osasuna.
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