Erling Haaland and Kylian Mbappe took advantage of injuries to the leaders in the European Golden Shoe rankings by scoring decisive doubles at the weekend.
Both players moved on to 23 league goals for the season and 46 points in the standings for the most goals in Europe.
Leader Robert Lewandowski has not played for a month due to a knee injury he suffered with Poland.
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Ronaldo is on a run of nine goals from his last nine appearances (eight starts) in Serie A and Juve were beaten 1-0 without him on Sunday.
Missing the game was a blow to his hopes of catching Lewandowski, who still sits in a commanding position in the standings with 35 league goals and 70 Golden Shoe points.
Lionel Messi is in a tie for third place with Mbappe, Haaland and Andre Silva.
He had a successful weekend as Barcelona won the Copa del Rey, though his two goals in the final against Athletic do not count in this competition.
Messi has failed to net in his last two La Liga matches against Real Valladolid and Real Madrid.
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Ronaldo continues to hold an advantage over Messi of two goals, with Lewandowski 12 better off than the Barcelona star in the Golden Shoe rankings.
Silva missed the chance to move ahead of Messi in the European Golden Shoe as Frankfurt were thrashed 4-0 by Gladbach.
The double for Haaland, meanwhile, was a welcome performance for the Norway striker, who was appearing to run out of steam towards the end of the season.
Haaland had not netted in seven matches for club or country prior to his strikes against Bremen, one of which came from the penalty spot.
However, Mbappe has been on consistent goalscoring form, scoring seven times in his last six Ligue 1 appearances.
Romelu Lukaku did not score as Inter drew 1-1 at Napoli, meaning he stays on 21 goals in the European Golden Shoe standings.
Gerard Moreno moved up to 20 goals in the Golden Shoe charts, putting him ahead of Mohamed Salah, Luis Suarez, Karim Benzema and Wout Weghorst, who all have 38 points.
Paul Onuachu of Genk has 29 goals and would be comfortably clear sitting second in the standings – rather than his current position of seventh - if he played in a major league with a better weighting for points.
Lewandowski looks like he will be the eventual winner of the European Golden Shoe race even though he has had a prolonged injury absence.
Still holding a lead of 20 points on Ronaldo, Bayern star Lewandowski is on track to win his first Golden Shoe trophy as we hit the final weeks of the campaign.
Lewandowski would become the first Bundesliga winner since 1972 if he does hold on to his advantage.
2020/21 EUROPEAN GOLDEN SHOE STANDINGS
2020/21 European Golden Shoe
|Luis Suarez||Atletico Madrid||19||38|
|Karim Benzema||Real Madrid||19||38|
|Wissam Ben Yedder||Sevilla||17||34|
|Isaac Kiese Thelin||Kasimpasa||22||33|
|Bruno Fernandes||Man Utd||16||32|
2020/21 EUROPEAN GOLDEN SHOE (Summer Leagues)
2020 European Golden Shoe
|Rauno Sappinen||Flora Tallinn||26||26|
|Mushaga Bakenga||Odds BK||15||22.5|
|Maksim Skavysh||BATE Borisov||19||19|
Who are the previous European Golden Shoe winners?
European Golden Shoe winners
|2014/15||Cristiano Ronaldo||Real Madrid||48|
|2010/11||Cristiano Ronaldo||Real Madrid||40|
Lionel Messi has won the most European Golden Shoe titles.
The Barcelona forward has triumphed on six occasions, most recently in 2018/19.
Nine players have two awards apiece, including Luis Suarez and Thierry Henry.
Messi holds the record for most goals and points in a season as well. He remarkably scored 50 goals in 2011/12, earning himself 100 points.
Ronaldo has come closest to breaking that, scoring 48 goals for 96 points when he last won the crown six years ago.
Argentina forward Messi is the only player in European Golden Shoe history to win the title three years in a row, doing so from 2016 until 2019.
Ronaldo, though, is one of only four players to have won the title with different clubs. The others are Luis Suarez, Diego Forlan and Mario Jardel.
It was his first title, with the striker becoming the first Serie A player to have the most goals in Europe since Francesco Totti triumphed for Lazio's rivals Roma in 2006/07.
Ligue 1 has not produced a winner since Josip Skoblar in 1971.
What are the European Golden Shoe rules and weightings?
Only league goals are eligible for the European Golden Shoe, with each strike earning points in a weighted system depending on the quality of league.
The five elite leagues - Premier League, La Liga, Bundesliga, Serie A and Ligue 1 - all carry a weighting of 2, meaning that a player will be awarded two points for every goal they score in these competitions.
For the leagues ranked sixth to 21 in Uefa's coefficients rankings - which includes the top-flights in Portugal, Netherlands and Russia - goals scored are given a weighting of 1.5, and goals scored in a league outwith the top 21 are given a weighting of 1.
That was not always the case in the European Golden Shoe. From 1968 until 1991, the award simply went to the highest goalscorer on the continent, regardless of the strength of league.
Awards were not initially handed out between 1991 until 1996, when the new system came into force. Since then, only two players playing outside what were the five highest-ranked leagues at the time have ever won the Golden Shoe - Henrik Larsson (2000/01) and Mario Jardel (2001/02).
The Golden Shoe has been tied in the past, most recently when Suarez and Ronaldo shared the honour in 2013/14. Going forward, though, the award will be given to the player who has played the fewest minutes if two of them end up on the same number of points.
This page covers the 2020/21 European Golden Shoe race. If you want to see the final standings for the 2019/20 European Golden Shoe, follow this link.